DNA Sequencing by Recognition and Its Potential Application with Nanopore Sequencing

ISSN: 1875-5348 (Online)
ISSN: 1385-2728 (Print)


Volume 18, 24 Issues, 2014


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Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: coc@benthamscience.org

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DNA Sequencing by Recognition and Its Potential Application with Nanopore Sequencing

Author(s): Feng Liang, Yan Zeng and Lei Wang

Affiliation: College of Chemical Engineering and Technology, Wuhan University of Science and Technology, Wuhan 430081, China.

Abstract

Nanopore based DNA Sequencing by Recognition technique relies on reading electrical current in a tiny circuit composed of a DNA nucleotide trapped between a pair of electrodes, which span a nanopore. The electrodes are made by functionalizing the tip of a scanning tunneling microscope (STM), with recognition molecules that can distinguish individual DNA bases through hydrogen bonds. This manuscript aims to provide a summary of current research progress of nanopore DNA sequencing, DNA Sequencing by Recognition, evolution of recognition molecules applied in Sequencing by Recognition, and discusses the opportunities and challenges in this rapidly growing field.


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Article Details

Volume: 19
First Page: 1
Last Page: 1
Page Count: 1
DOI: 10.2174/1385272819666140514004615
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