DNA Sequencing by Recognition and Its Potential Application with Nanopore Sequencing
Feng Liang, Yan Zeng and Lei WangAffiliation:
College of Chemical Engineering and Technology, Wuhan University of Science and Technology, Wuhan 430081, China.
AbstractNanopore based DNA Sequencing by Recognition technique relies on reading electrical current in a tiny circuit composed of a DNA nucleotide trapped between a pair of electrodes, which span a nanopore. The electrodes are made by functionalizing the tip of a scanning tunneling microscope (STM), with recognition molecules that can distinguish individual DNA bases through hydrogen bonds. This manuscript aims to provide a summary of current research progress of nanopore DNA sequencing, DNA Sequencing by Recognition, evolution of recognition molecules applied in Sequencing by Recognition, and discusses the opportunities and challenges in this rapidly growing field.
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