Novel Dibenzothiepins with Antibiofilm Activity Demonstrated by Microbiological Assays and Molecular Modeling

ISSN: 1875-5348 (Online)
ISSN: 1385-2728 (Print)


Volume 18, 24 Issues, 2014


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Current Organic Chemistry

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Novel Dibenzothiepins with Antibiofilm Activity Demonstrated by Microbiological Assays and Molecular Modeling

Author(s): Camelia Elena Stecoza, Magdalena Majekova, Pavol Majek, Miron Teodor Caproiu and Luminita Marutescu

Affiliation: Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, Dubravska cesta 9, 84104 Bratislava, Slovakia.

Abstract

New dibenzo[b,e]thiepins were synthesized, characterized by elemental analysis, spectral studies (1H-NMR, 13C-NMR, IR) and screened for their microbicidal and antibiofilm properties. The new dibenzo[b,e]thiepins and their sulfones exhibited a broad spectrum of antimicrobial activity (superior for the S-oxidized compounds) being effective at low concentrations against a wide range of infectious microorganisms. The oximes exhibited anti- A. baumanii activity.

Some of the compounds exhibited good antibiofilm activity against the Gram-negative, non-fermentative bacilli P. aeruginosa and A. baumanii, and their possible target suggested by molecular modeling being the synthesis of the quorum sensing molecules employed by the Gram-negative microorganisms represented by N-acyl-l-homoserine lactones.


Keywords: Dibenzothiepins, Anti-biofilm activity, Molecular modelling, A. baumanii

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Article Details

Volume: 17
Issue Number: 2
First Page: 113
Last Page: 124
Page Count: 12
DOI: 10.2174/1385272811317020006
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