Deep Brain Stimulation: A New Treatment in Mood and Anxiety Disorders

ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)

Volume 14, 10 Issues, 2015

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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

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Stephen D. Skaper
Department of Pharmaceutical and Pharmacological Sciences
University of Padova

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Deep Brain Stimulation: A New Treatment in Mood and Anxiety Disorders

CNS & Neurological Disorders - Drug Targets, 13(6): 961-971.

Author(s): Bruna Velasques, Claudia Diniz, Silmar Teixeira, Consuelo Cartier, Caroline Peressutti, Farmy Silva, Marcele de Carvalho, Aline Novaes, Juliana Bittencourt, Antonio Egidio Nardi, Elie Cheniaux, Luis Basile, Mauricio Cagy, Roberto Piedade and Pedro Ribeiro.

Affiliation: Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil.


This article considered already existing studies about Deep Brain Stimulation in Mood and Anxiety Disorders. In particular, articles regarding Obsessive-Compulsive Disorder and Major Depression were mostly analyzed, due to the lack of researches about other types of Mood and Anxiety Disorders. We have concentrated on the target areas where Deep Brain Stimulation was most commonly applied, and on the effects this measure had on treatment-refractory patients. The obtained results showed that the stimulation of the: nucleus accumbens, subgenual cingulate cortex and ventral capsule/ventral striatum, has a positive influence on the development of the disorders investigated, sometimes showing the complete remission of the symptoms. Although Deep Brain Stimulation was overall found to be a promising and safe treatment for Mood and Anxiety Disorders, there are not enough studies proving its efficacy in wide samples and in the presence of more complex variables.


Anxiety disorder, deep brain stimulation, depression, obsessive compulsive disorder.

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Article Details

Volume: 13
Issue Number: 6
First Page: 961
Last Page: 971
Page Count: 11
DOI: 10.2174/1871527313666140612122929

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