Current Directions in Non-Invasive Low Intensity Electric Brain Stimulation for Depressive Disorder

ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)

Volume 15, 10 Issues, 2016

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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

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Stephen D. Skaper
Department of Pharmaceutical and Pharmacological Sciences
University of Padova

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Current Directions in Non-Invasive Low Intensity Electric Brain Stimulation for Depressive Disorder

CNS & Neurological Disorders - Drug Targets, 13(6): 945-952.

Author(s): Dennis J.L.G. Schutter and Alexander T Sack.

Affiliation: Department of Neurocognition, Faculty of Psychology and Neuroscience, Maastricht University, Universiteitssingel 40 East, 6229 ER Maastricht, The Netherlands.


Non-invasive stimulation of the human brain to improve depressive symptoms is increasingly finding its way in clinical settings as a viable form of somatic treatment. Following successful modulation of neural excitability with subsequent antidepressant effects, neural polarization by administrating weak direct currents to the scalp has gained renewed interest. A new wave of basic and clinical studies seems to underscore the potential therapeutic value of direct current stimulation in the treatment of depression. Issues concerning the lack of mechanistic insights into the workings of modifying brain function through neural polarization and how this process translates to its antidepressant properties calls for additional research. The range of its clinical applicability has yet to be established.


Depressive disorder, non-invasive brain stimulation, transcranial direct current stimulation, treatment.

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Article Details

Volume: 13
Issue Number: 6
First Page: 945
Last Page: 952
Page Count: 8
DOI: 10.2174/1871527313666140612115123

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