Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa

ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)

Volume 14, 10 Issues, 2015

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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

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Stephen D. Skaper
Department of Pharmaceutical and Pharmacological Sciences
University of Padova

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Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa

CNS & Neurological Disorders - Drug Targets, 13(6): 953-960.

Author(s): Alexandre R. de Mello Schier, Natalia P. de Oliveira Ribeiro, Danielle S. Coutinho, Sergio Machado, Oscar Arias-Carrion, Jose A. Crippa, Antonio W. Zuardi, Antonio E. Nardi and Adriana C Silva.

Affiliation: Institute of Psychiatry - Federal University of Rio de Janeiro. Laboratory of Panic and Respiration. Rua Visconde de Piraja, 407/702, Rio de Janeiro, RJ. CEP 22410-003, Brazil.


Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life, productivity and health. Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound. The aim of this study is to review studies of animal models using CBD as an anxiolytic-like and antidepressant-like compound. Studies involving animal models, performing a variety of experiments on the above-mentioned disorders, such as the forced swimming test (FST), elevated plus maze (EPM) and Vogel conflict test (VCT), suggest that CBD exhibited an anti-anxiety and antidepressant effects in animal models discussed. Experiments with CBD demonstrated non-activation of neuroreceptors CB1 and CB2. Most of the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor.


Anxiety, anxiolytic-like, cannabis sativa, cannabidiol, CBD, major depression.

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Article Details

Volume: 13
Issue Number: 6
First Page: 953
Last Page: 960
Page Count: 8
DOI: 10.2174/1871527313666140612114838

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