Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death
Pradeep Hanumanthappa, Asha Densi and Rajanikant Golgodu KrishnamurthyAffiliation:
Associate Professor & Head, School of Biotechnology, Coordinator, DBT - Centre for Bioinformatics, National Institute of Technology Calicut, Calicut - 673601, India.
AbstractGlycogen synthase kinase 3 β (GSK- 3 β ) is implicated in diverse cellular processes such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3 β activity contributes to neuronal death and pathogenesis of ischemic stroke. Considering predominant roles of GSK-3 β in neuronal apoptosis, modulation of this protein kinase is a reliable strategy for ischemic neuroprotection. In this review, we survey and synthesize the current knowledge about the role of GSK-3 β in neuroprotection following the ischemic stroke.
Apoptosis, brain, GSK-3 β , hypoxia, ischemic stroke, neuronal death.
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