Glycogen Synthase Kinase-3β in Ischemic Neuronal Death

ISSN: 1875-5739 (Online)
ISSN: 1567-2026 (Print)


Volume 11, 4 Issues, 2014


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Current Neurovascular Research

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Glycogen Synthase Kinase-3β in Ischemic Neuronal Death

Author(s): H Pradeep, Asha Densi and G. K Rajanikant

Affiliation: Centre for Bioinformatics National Institute of Technology Calicut Calicut - 673601, India

Abstract

Glycogen synthase kinase 3β (GSK-3β) is implicated in diverse cellular processess such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3β activity contributes to neuronal death and to the pathogenesis of ischemic stroke. Considering predominant roles of GSK-3β in neuronal apoptosis, manipulation of this protein kinase is a promising strategy for ischemic neuroprotection. In this review, we survey and synthesize the current knowledge about the role of GSK-3β in neuroprotection following the ischemic stroke

Keywords: Apoptosis, brain, GSK-3β, hypoxia, ischemic stroke, neuronal death

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Article Details

Volume: 11
First Page: 1
Last Page: 8
Page Count: 8
DOI: 10.2174/1567202611666140520151002
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