Affiliation: Associate Professor & Head, School of Biotechnology, Coordinator, DBT - Centre for Bioinformatics, National Institute of Technology Calicut, Calicut - 673601, India.
Glycogen synthase kinase 3 β (GSK- 3 β ) is implicated in diverse cellular processes such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3 β activity contributes to neuronal death and pathogenesis of ischemic stroke. Considering predominant roles of GSK-3 β in neuronal apoptosis, modulation of this protein kinase is a reliable strategy for ischemic neuroprotection. In this review, we survey and synthesize the current knowledge about the role of GSK-3 β in neuroprotection following the ischemic stroke.