Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death

ISSN: 1875-5739 (Online)
ISSN: 1567-2026 (Print)

Volume 12, 4 Issues, 2015

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Current Neurovascular Research

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Prof. Kenneth Maiese
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Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death

Author(s): Pradeep Hanumanthappa, Asha Densi and Rajanikant Golgodu Krishnamurthy

Affiliation: Associate Professor & Head, School of Biotechnology, Coordinator, DBT - Centre for Bioinformatics, National Institute of Technology Calicut, Calicut - 673601, India.


Glycogen synthase kinase 3 β (GSK- 3 β ) is implicated in diverse cellular processes such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3 β activity contributes to neuronal death and pathogenesis of ischemic stroke. Considering predominant roles of GSK-3 β in neuronal apoptosis, modulation of this protein kinase is a reliable strategy for ischemic neuroprotection. In this review, we survey and synthesize the current knowledge about the role of GSK-3 β in neuroprotection following the ischemic stroke.

Keywords: Apoptosis, brain, GSK-3 β , hypoxia, ischemic stroke, neuronal death.

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Article Details

Volume: 11
Issue Number: 3
First Page: 271
Last Page: 278
Page Count: 8
DOI: 10.2174/1567202611666140520151002

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