Protection of Blood Brain Barrier Integrity and Modulation of Inflammatory Mediators During Treatment of Pneumococcal Meningitis with Daptomycin or Ceftriaxone

ISSN: 1875-5739 (Online)
ISSN: 1567-2026 (Print)


Volume 11, 4 Issues, 2014


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Current Neurovascular Research

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Protection of Blood Brain Barrier Integrity and Modulation of Inflammatory Mediators During Treatment of Pneumococcal Meningitis with Daptomycin or Ceftriaxone

Author(s): Tatiana Barichello, João Carlos N. Gonçalves, Jaqueline S. Generoso, Lutiana R. Simoes, Michael H. Tashiro, Jéssica A. Goularte, Francieli Vuolo, David Henrique Rodrigues, Márcia Carvalho Vilela, Fabricia Petronilho, Antonio Lucio Teixeira and João Quevedo

Affiliation: Laboratório de Microbiologia Experimental, PPGCS, UNASAU, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil

Abstract

Pneumococcal meningitis is associated with neurologic sequelae, such as, learning and memory impairment. Most currently a nonbacteriolytic antibiotic has been investigated to minimize inflammatory host response and prevented cognitive damage. In the present study, we compared daptomycin (DPTO) or ceftriaxone (CFX) treatment on inflammatory parameters and on blood-brain barrier (BBB) integrity in experimental pneumococcal meningitis. In the first step, the animals received an intracisternal (i.c.) injection of 10 µl of a S. pneumoniae suspension and were treated with CFX or DPTO at 18 h and were killed at 18, 20, 24, 36 and 40 h. In the hippocampus, tumor necrosis factor-alpha (TNF-α), Interleukin-6 (IL-6), IL-10 and brain-derived neurotrophic factor (BDNF) levels were not different between both treatments, however, IL-4 and CINC-1 levels decreased in CFX group. In frontal cortex, TNF-α, IL-4, IL-6, IL-10 and BDNF levels were not different between both treatments. Only cytokine-induced neutrophil chemoattractant-1 (CINC-1) levels decreased at 40 h with CFX treatment. In the second step the animals received DPTO or CFX during 7 days and were killed 10 days after induction. TNF-α, IL-6, IL-10, CINC-1 and BDNF levels were not different between both treatments in the hippocampus, however, IL-4 levels decreased in CFX treatment. In the third step: the animals received by i.c. 10 µl of a S. pneumoniae suspension or artificial CSF and were treated with CFX or DTPO with a single dose of antibiotic and BBB breakdown was assessed; however both antibiotics prevented the BBB disruption. Equally both treatments protected the BBB integrity and there were no significant difference in cytokines production

Keywords: BDNF, ceftriaxone, cytokine, daptomycin, meningitis, Streptococcus pneumonia

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Article Details

Volume: 11
First Page: 1
Last Page: 13
Page Count: 13
DOI: 10.2174/1567202611666140520123424
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