Neuroinflammation: Microglial Activation During Sepsis

ISSN: 1875-5739 (Online)
ISSN: 1567-2026 (Print)

Volume 11, 4 Issues, 2014

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Current Neurovascular Research

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Neuroinflammation: Microglial Activation During Sepsis

Author(s): Monique Michels, Lucinéia Gainski Danielski, Felipe Dal-Pizzol and Fabrícia Petronilho

Affiliation: Laboratory of Clinical and Experimental Pathophysiology Posgtraduate Program in Health Sciences University of South of Santa Catarina Tubarão, SC, Brazil


Neuroinflammation is largely described in the acute phase after brain injury, as well as in chronic brain diseases. Cells that are directly or indirectly involved in immune responses compose the Central Nervous System. Microglia are resident cells of the central nervous system and, as peripheral macrophages, are activated in the presence of some cellular insult, producing a large number of cytokines and chemokines in order to remove toxins from the extracellular space. This activation can lead to a breakdown of the blood-brain barrier, production of reactive oxygen species that is involved in the progression of brain damage as occurs in septic encephalopathy. Given the growing importance of microglia in the field of neurotoxicology, we describe the role of microglia and the cellular mechanisms that activate these cells during sepsis. Thus, in this review we focused in the relationship between microglia and neuroinflammation associated with sepsis

Keywords: Blood-brain barrier, CNS, Encephalopathy, Microglia, Neuroinflammation, Sepsis

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Article Details

Volume: 11
First Page: 1
Last Page: 8
Page Count: 8
DOI: 10.2174/1567202611666140520122744

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