Basal Ganglia Enlarged Perivascular Spaces are Linked to Cognitive Function in Patients with Cerebral Small Vessel Disease

ISSN: 1875-5739 (Online)
ISSN: 1567-2026 (Print)

Volume 14, 4 Issues, 2017

Download PDF Flyer

Current Neurovascular Research

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Prof. Kenneth Maiese
Neurology and Neurosciences UMDNJ
205 South Orange Avenue, F1220
Newark, NJ 07101

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.123
5 - Year: 2.459

Basal Ganglia Enlarged Perivascular Spaces are Linked to Cognitive Function in Patients with Cerebral Small Vessel Disease

Current Neurovascular Research, 11(2): 136-141.

Author(s): Marjolein Huijts, Annelien Duits, Julie Staals, Abraham A Kroon, Peter W de Leeuw and Robert J van Oostenbrugge.

Affiliation: Department of Neurology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht , The Netherlands.


Enlarged perivascular spaces (EPVS) are a feature of cerebral small vessel disease (cSVD) and have been related to cSVD severity. A higher number of EPVS were related to decreased cognition in healthy elderly, but this has never been investigated in patients at high risk of cSVD. We included 189 patients with a high risk of cSVD (hypertensive patients and lacunar stroke patients). Patients underwent brain MRI and extensive neuropsychological assessment. EPVS were rated in the basal ganglia (BG) and centrum semiovale (CSO). Correlation analyses between EPVS and cognitive domains were adjusted for white matter lesions (WMLs), age, sex and symptomatic stroke. Negative correlations were found between EPVS in the BG and all cognitive domains, independent of WMLs. After correction for age, results remained significant for information processing speed (IPS) only. No independent correlation was found between EPVS in the CSO and cognition. We demonstrated that more BG EPVS were associated with a decrease in IPS, independent of age and WMLs. This emphasizes that specifically EPVS in the BG are associated with cSVD, and with cSVD-related decreases in cognition.


Cerebral small vessel disease, cognition, enlarged perivascular spaces, hypertension, lacunar stroke, white matter lesions.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 11
Issue Number: 2
First Page: 136
Last Page: 141
Page Count: 6
DOI: 10.2174/1567202611666140310102248
Price: $58
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

Related Journals

Related eBooks

Webmaster Contact: Copyright © 2017 Bentham Science