Hyper-Coagulable Profile with Elevated Pro-Thrombotic Biomarkers and Increased Cerebro- and Cardio-Vascular Disease Risk Exist Among Healthy Dyslipidemic Women

ISSN: 1875-5739 (Online)
ISSN: 1567-2026 (Print)


Volume 11, 4 Issues, 2014


Download PDF Flyer




Current Neurovascular Research

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 74th of 194 in Clinical Neurology

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Prof. Kenneth Maiese
Neurology and Neurosciences UMDNJ
205 South Orange Avenue, F1220
Newark, NJ 07101
USA
Email: wntin75@yahoo.com

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.735
5 - Year: 2.835

Hyper-Coagulable Profile with Elevated Pro-Thrombotic Biomarkers and Increased Cerebro- and Cardio-Vascular Disease Risk Exist Among Healthy Dyslipidemic Women

Author(s): Claudia N. Ferreira, Maria G. Carvalho, Helton J. Reis, Karina B. Gomes, Marinez O. Sousa and Andras Palotas

Affiliation: Asklepios-Med, H-6722 Szeged, Kossuth Lajos sgt. 23, Hungary.

Abstract

Dyslipidemia is one of the pathognomonic elements of athero-genesis, as well as cerebro- and cardio-vascular disease (CCVD). Hemostatic factors are also involved in athero-sclerosis and ischemic changes, however their relationship with disrupted lipid homeostasis is not well characterized. The aim of this study was to determine the coagulation state of dyslipidemic patients and to evaluate their association with CCVD risk factors. Biochemical and hematological parameters, as well as neuro-psychiatric profile of 109 dyslipidemic subjects and 107 normo-lipidic healthy volunteers were assessed. Serum bio-marker levels and cognitive performance generally did not differ in the groups, but prothrombin fragment 1+2 (F1+2) and D-dimer concentrations were markedly higher among women. Hyper-coagulability was not associated with dyslipidemia, but was correlated with the female gender, which might pose an increased thromboembolic risk in asymptomatic women.

Keywords: Cerebro- and cardio-vascular disease (CCVD), D-dimer, dyslipidemia, prothrombin fragment 1+2 (F1+2), risk factor.

Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 11
Issue Number: 2
First Page: 142
Last Page: 148
Page Count: 7
DOI: 10.2174/1567202611666140307104724
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science