Behavior of EDTMP (Ethylene-diaminetetramethylene-phosphonate)- Nanoparticles in Blood: Considerations on the Site of Injection

ISSN: 1875-6786 (Online)
ISSN: 1573-4137 (Print)


Volume 10, 6 Issues, 2014


Download PDF Flyer




Current Nanoscience

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 41st of 69 in Nanoscience & Nanotechnology
  • 106th of 241 in Materials Science, Multidisciplinary
  • 111th of 160 in Biotechnology & Applied Microbiology

Submit Abstracts Online Submit Manuscripts Online

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 1.356
5 - Year: 1.64

Behavior of EDTMP (Ethylene-diaminetetramethylene-phosphonate)- Nanoparticles in Blood: Considerations on the Site of Injection

Author(s): Beatriz Ferreira de Carvalho Patricio, Osmar Flavio da Silveira Leite Neto, Marta de Souza Albernaz and Ralph Santos-Oliveira

Affiliation: Nuclear Engineering Institute, Rua Helio de Almeida 75 – Rio de Janeiro – Brazil.

Abstract

The nanotechnology and the use of nanoparticles are increasing each day. The number of experiments with nanoparticles is enormous and is corroborating the use in humans. However some points must be more defined before a final approval. In this study we analyzed nanoparticles of EDTMP under different conditions in rats and observed some characteristics that should be taken into account. Nanoparticles were injected either intraocular or in a jugular vein, and the data were compared. The behaviors of the samples were very different, which may have led to erroneous interpretation of nanoparticle data in previous studies by many authors. In all cases, the results of the biodistribution were quite different, which may lead to different conclusions. Analyzing the data, we conclude that the biodistribution test should be standardized, and the way that it is conducted may change the final results drastically.




Keywords: Animal model, biodistribution, cancer, nanotechnology, oncology.

Purchase Online Rights and Permissions

Article Details

Volume: 10
Issue Number: 3
First Page: 323
Last Page: 325
Page Count: 3
DOI: 10.2174/1573413709666131203231623
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science