Neurodegeneration in Diabetic Retina and its Potential Drug Targets

ISSN: 1875-6190 (Online)
ISSN: 1570-159X (Print)


Volume 12, 6 Issues, 2014


Download PDF Flyer




Current Neuropharmacology

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 121st of 254 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
T.E. Salt
University College London
Institute of Ophthalmology
London EC1V 9EL
UK


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.347
5 - Year: 3.856

Neurodegeneration in Diabetic Retina and its Potential Drug Targets

Author(s): Mohammad Shamsul Ola and Abdullah S. Alhomida

Affiliation: Department of Biochemistry, College of Science, King Saud University, Riyadh, KSA.

Abstract

Diabetic retinopathy (DR) is one of the major complications of diabetes causing vision loss and blindness worldwide. DR is widely recognized as a neurodegenerative disease as evidenced from early changes at cellular and molecular levels in the neuronal component of the diabetic retina, which is further supported by various retinal functional tests indicating functional deficits in the retina soon after diabetes progression. Diabetes alters the level of a number of neurodegenerative metabolites, which increases influx through several metabolic pathways which in turn induce an increase in oxidative stress and a decrease in neurotrophic factors, thereby damage retinal neurons. Loss of neurons may implicate in vascular pathology, a clinical signs of DR observed at later stages of the disease. Here, we discuss diabetes-induced potential metabolites known to be detrimental to neuronal damage and their mechanism of action. In addition, we highlight important neurotrophic factors, whose level have been found to be dysregulated in diabetic retina and may damage neurons. Furthermore, we discuss potential drugs and strategies based on targeting diabetes-induced metabolites, metabolic pathways, oxida¬tive stress, and neurotrophins to protect retinal neurons, which may ameliorate vision loss and vascular damage in DR.


Purchase Online Rights and Permissions

  
  



Article Details

Volume: 12
First Page: 1
Page Count: 1
DOI: 10.2174/1570159X12666140619205024
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science