Evidence for an Immune Role on Cognition in Schizophrenia: A Systematic Review

ISSN: 1875-6190 (Online)
ISSN: 1570-159X (Print)


Volume 12, 6 Issues, 2014


Download PDF Flyer




Current Neuropharmacology

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 121st of 254 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
T.E. Salt
University College London
Institute of Ophthalmology
London EC1V 9EL
UK


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.347
5 - Year: 3.856

Evidence for an Immune Role on Cognition in Schizophrenia: A Systematic Review

Author(s): Rafael Ribeiro-Santos, Antonio Lucio Teixeira and Joao Vinicius Salgado

Affiliation: Neurosciences Program, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Abstract

Objective: Recent evidence has associated immune and inflammatory changes to cognitive performance in many diseases, including schizophrenia. Since this is a new research field where concepts are not yet solid and new questions and hypothesis are still arising, the present study aimed at summarizing the available clinical data associating schizophrenia, cognition and inflammation/immune function.

Methods: A systematic review of the literature was made by searching the following terms in Medline: “schizophrenia or psychosis or psychotic” AND “inflamm* or immun* or cytokine or IL-* or TNF-* or kynureni* or KYNA”, AND “cognit* or attention or memory or executive function”.

Results: Seventy five papers were identified using the selected terms, and seven papers were included in the review. Papers excluded focused mainly on basic research or other neuropsychiatric disorders.

Conclusions: Recent findings link inflammatory markers to cognition in schizophrenia, suggesting that inflammation is associated with worst cognitive performance. Microglial activation, monoaminergic imbalance, brain abnormalities and the kynurenine pathway are possible mechanisms underlying cognitive impairment in schizophrenia. Clinical trials with addition of immunomodulatory drugs have shown promising results, opening new windows to tackle cognition in schizophrenia.


Keywords: Cognition, immunology, inflammation, schizophrenia.

Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 12
Issue Number: 3
First Page: 273
Last Page: 280
Page Count: 8
DOI: 10.2174/1570159X1203140511160832
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science