Anti-cancer Drug Discovery: Update and Comparisons in Yeast, Drosophila, and Zebrafish

ISSN: 1874-4702 (Online)
ISSN: 1874-4672 (Print)

Volume 8, 2 Issues, 2015

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Current Molecular Pharmacology

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Michael Kahn
University of Southern California
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Anti-cancer Drug Discovery: Update and Comparisons in Yeast, Drosophila, and Zebrafish

Current Molecular Pharmacology, 7(1): 44-51.

Author(s): Guangxun Gao, Liang Chen and Chuanshu Huang.

Affiliation: Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA.


Discovery of novel cancer chemotherapeutics focuses on screening and identifying compounds that can target ‘cancer-specific’ biological processes while causing minimal toxicity to non-tumor cells. Alternatively, model organisms with highly conserved cancer-related cellular processes relative to human cells may offer new opportunities for anticancer drug discovery when combined with chemical screening. Some organisms used for chemotherapeutic discovery include yeast, Drosophila, and zebrafish which are similar in important ways relevant to cancer study but offer distinct advantages as well. Here, we describe these model attributes and the rationale for using them in cancer drug screening research.


Anti-cancer drug discovery, Drosophila, HTS, model organism, yeast, zebrafish.

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Article Details

Volume: 7
Issue Number: 1
First Page: 44
Last Page: 51
Page Count: 8
DOI: 10.2174/1874467207666140702113629

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