Anti-cancer Drug Discovery: Update and Comparisons in Yeast, Drosophila, and Zebrafish

ISSN: 1874-4702 (Online)
ISSN: 1874-4672 (Print)


Volume 8, 2 Issues, 2015


Download PDF Flyer




Current Molecular Pharmacology

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Michael Kahn
University of Southern California
1450 Biggy Street
Los Angeles, NRT 4501, CA 90033
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Anti-cancer Drug Discovery: Update and Comparisons in Yeast, Drosophila, and Zebrafish



Current Molecular Pharmacology, 7(1): 44-51.

Author(s): Guangxun Gao, Liang Chen and Chuanshu Huang.

Affiliation: Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA.

Abstract

Discovery of novel cancer chemotherapeutics focuses on screening and identifying compounds that can target ‘cancer-specific’ biological processes while causing minimal toxicity to non-tumor cells. Alternatively, model organisms with highly conserved cancer-related cellular processes relative to human cells may offer new opportunities for anticancer drug discovery when combined with chemical screening. Some organisms used for chemotherapeutic discovery include yeast, Drosophila, and zebrafish which are similar in important ways relevant to cancer study but offer distinct advantages as well. Here, we describe these model attributes and the rationale for using them in cancer drug screening research.

Keywords:

Anti-cancer drug discovery, Drosophila, HTS, model organism, yeast, zebrafish.



Download Free Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 7
Issue Number: 1
First Page: 44
Last Page: 51
Page Count: 8
DOI: 10.2174/1874467207666140702113629
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2015 Bentham Science