Role of MicroRNAs in B Cell Leukemias and Lymphomas

ISSN: 1875-5666 (Online)
ISSN: 1566-5240 (Print)


Volume 14, 10 Issues, 2014


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Current Molecular Medicine

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David W. Li
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University of Nebraska Medical Center
Omaha, NE
USA


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Role of MicroRNAs in B Cell Leukemias and Lymphomas

Author(s): A. Schmidt and R. Kuppers

Affiliation: Institute of Cell Biology (Cancer Research), Faculty of Medicine, University of Duisburg-Essen, Virchowstr. 173, 45122 Essen, Germany.

Abstract

MicroRNAs (miRNAs) are a class of small (18~25 nucleotides long) non-coding RNAs that regulate gene expression on the post-transcriptional level. During the last decade, the field of miRNA research has been exponentially expanding, revealing the widespread role of these molecules in numerous biological processes. Aberrant miRNA expression has been documented in multiple haematologic malignancies, including B cell lymphomas. There is compelling evidence that miRNAs can function as oncogenes or tumor suppressor genes in lymphoid malignancies. In this review, we recapitulate the current knowledge of miRNA expression in B cell malignancies and discuss the accumulating evidence for a major role of miRNA deregulation in the development of B cell-derived lymphoid tumors.

Keywords: B cells, Hodgkin lymphoma, leukemia, lymphoma, MicroRNA.

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Article Details

Volume: 14
Issue Number: 5
First Page: 580
Last Page: 597
Page Count: 18
DOI: 10.2174/1566524014666140603095414
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