Microwave Assisted Synthesis of ethyl-quinolon-4-one-3-carboxylates and Hydrolysis to quinolon-4-one-3-carboxylic Acids

ISSN: 2213-3364 (Online)
ISSN: 2213-3356 (Print)


Volume 1, 2 Issues, 2014






Current Microwave Chemistry

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Community Health Systems of South Texas (CHSST)
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Microwave Assisted Synthesis of ethyl-quinolon-4-one-3-carboxylates and Hydrolysis to quinolon-4-one-3-carboxylic Acids

Author(s): Ivana Malvacio, D. Mariano. A. Vera and Elizabeth L. Moyano

Affiliation: INFIQC - Organic Chemistry Department, School of Chemical Sciences, National University of Cordoba, Cordoba, CP 5000, Argentine.

Abstract

A fast and efficient microwave assisted synthesis of several ethyl-quinolon-4-one-3-carboxylates and quinolon- 4-one-3-carboxylic acids has been developed. The 3-carboethoxy quinolones are easily obtained in a one-pot procedure through the cyclization of aminomethylenemalonate intermediates obtained by reaction of different p-substituted anilines and diethyl-ethoxymethylenmalonate. These quinolones are then irradiated under base hydrolysis conditions to get the carboxylic acids through a very fast and clean approach.




Keywords: Carboxylic acids, catalysis, cyclization, hydrolysis, malonates, microwave, open-vessel, quinolones, sealed-vessel, thermolysis.

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Article Details

Volume: 1
Issue Number: 1
First Page: 52
Last Page: 58
Page Count: 7
DOI: 10.2174/2213335601666140402002204
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