A Rapid Protocol for the Synthesis of N-[2-(alkyl/aryl)-4-phenyl-1Himidazol- 1-yl] benzamides via Microwave Technique

ISSN: 2213-3364 (Online)
ISSN: 2213-3356 (Print)


Volume 2, 2 Issues, 2015


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Current Microwave Chemistry

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Community Health Systems of South Texas (CHSST)
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A Rapid Protocol for the Synthesis of N-[2-(alkyl/aryl)-4-phenyl-1Himidazol- 1-yl] benzamides via Microwave Technique



Current Microwave Chemistry, 1(1): 47-51.

Author(s): Fatih Yılmaz and Emre Mentese.

Affiliation: Department of Chemistry, Recep Tayyip Erdogan University, 53100, Rize, Turkey.

Abstract

Benzohydrazides (2a-g) were synthesized starting from iminoester hydrochlorides and benzhydrazide. The treatment of compounds 2a-g with phenylacyl bromide derivatives gave N-[2-(alkyl/aryl)-4-phenyl-1H-imidazol-1-yl] benzamides. The synthetic protocol was performed under microwave irradiation and the lowest quantity of the solvent was used to obtain the best green protocol. This method has been found to be more efficient than others in terms of green chemistry.




Keywords:

Acetamidrazone, amide hydrazone, benzamide, benzhydrazide, catalyst-free, hydrazide imide, imidazole, iminoester hydrochloride, green chemistry, microwave irradiation, phenylacyl bromide.



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Article Details

Volume: 1
Issue Number: 1
First Page: 47
Last Page: 51
Page Count: 5
DOI: 10.2174/2213335601999140221111915
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