Microwave Assisted Rapid Synthesis of β -Nitroalcohols

ISSN: 2213-3364 (Online)
ISSN: 2213-3356 (Print)

Volume 1, 2 Issues, 2014

Current Microwave Chemistry

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Bimal K. Banik
Department of Chemistry
College of Science & Mathematics
The University of Texas-Pan American
1201 West University Drive
Edinburg, Texas

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Microwave Assisted Rapid Synthesis of β -Nitroalcohols

Author(s): Pranjal P. Bora and Ghanashyam Bez

Affiliation: Department of Chemistry, North Eastern Hill University, Shillong-793022, India.


A major concern in base catalyzed Henry reaction for the synthesis of β-nitroalcohol from the reaction of aldehyde and nitroalkane is instantaneous formation of nitroalkene by dehydration, which in turn facilitates many side reactions. It is observed that rapid synthesis of β-nitroalcohol can be accomplished by carrying out the reaction in aqueous phosphate buffer at pH 7.0 under microwave irradiation without using any additional base. Use of microwave irradiation facilitated the formation of β-nitroalcohol within a very short time, yet no instantaneous formation of nitroalkene was observed even at 80 °C.

Keywords: Aldehyde, base-free, henry reaction, high temperature, microwave irradiation, β-nitroalcohol, nitroalkane, no side reaction, no diastereoselecivity, phosphate buffer, pH 7.0.

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Article Details

Volume: 1
Issue Number: 1
First Page: 59
Last Page: 63
Page Count: 5
DOI: 10.2174/2213335601666140124205109

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