Microwave Assisted Preparation of New Dicoumarinyl Pyrazoline Derivatives as Antimicrobials

ISSN: 2213-3364 (Online)
ISSN: 2213-3356 (Print)

Volume 4, 4 Issues, 2017

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Current Microwave Chemistry

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Bimal K. Banik
Vice President of Research & Education Development
Community Health Systems of South Texas (CHSST)
Edinburg, TX

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Microwave Assisted Preparation of New Dicoumarinyl Pyrazoline Derivatives as Antimicrobials

Current Microwave Chemistry, 1(1): 64-74.

Author(s): Hemali B. Lad, Rakesh R. Giri, Chirag V. Patel, Varun G. Bhila and Dinkar I Brahmbhatt.

Affiliation: Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar-388120, Gujarat, India.


Some new 3-[7-methoxy-2H-1-benzopyran-2-one-4-yl]-1-(coumarin-3-yl)prop-2-en-1-ones 5a-d (dicoumarinyl chalcones) were synthesized by Wittig reaction of 3-[(triphenylphosphinyl)acetenyl]coumarins 3a-d and 7-methoxy-4- formylcoumarin 4. These chalcones were then utilized for the synthesis of dicoumarinyl pyrazolines 6a-h and 7a-l under microwave irradiation. All the synthesized compounds 5a-d, 6a-h and 7a-l were characterized by IR, 1H NMR, 13C NMR, mass spectral data and elemental analysis. The compounds were subjected to in vitro antimicrobial screening against a representative panel of bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Salmonella typhi) and fungi (Aspergillus niger, Candida albicans).


Antimicrobial screening, aspergillus niger, bacillus subtilis, broth dilution method, candida albicans, diastereotopic protons, dicoumarinyl chalcones, dicoumarinyl pyrazolines, escherichia coli, 7-methoxy-4-formylcoumarin, microwave irradiation, salmonella typhi, staphylococcus aureus, 3-[(triphenylphosphinyl)- acetenyl]coumarins, wittig reaction.

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Article Details

Volume: 1
Issue Number: 1
First Page: 64
Last Page: 74
Page Count: 11
DOI: 10.2174/221333560101140519152017

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