New Drugs for HDL-C Disorders: The Beginning

ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)

Volume 23, 42 Issues, 2016

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Current Medicinal Chemistry

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Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge

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New Drugs for HDL-C Disorders: The Beginning

Current Medicinal Chemistry, 21(25): 2947-2951.

Author(s): MyNgan Duong and Stephen J Nicholls.

Affiliation: South Australian Health and Medical Research Institute. PO Box 11060. Adelaide, SA, 5001, Australia.


For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the potential clinical utility of this therapeutic target. A number of classes of agents are currently under investigation with variable effects on HDL quantity and quality. These will be reviewed.


Atherosclerosis, cardiovascular disease, HDL, lipids, risk factors.

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Article Details

Volume: 21
Issue Number: 25
First Page: 2947
Last Page: 2951
Page Count: 5
DOI: 10.2174/0929867321666140414104130
Price: $58

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