Four Major Factors Regulate Phosphatidylinositol 3-Kinasesignaling Pathwayin Cancers Induced by Infection of Human Papillomaviruses

ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)


Volume 21, 38 Issues, 2014


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Current Medicinal Chemistry

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Four Major Factors Regulate Phosphatidylinositol 3-Kinasesignaling Pathwayin Cancers Induced by Infection of Human Papillomaviruses

Author(s): Wu Jianhong, Jiezhong Chen, Lifang Zhang, Paul P. Masci and Kong-Nan Zhao

Affiliation: Centre for Kidney Disease-Venomics Research, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, QLD 4102, Australia

Abstract

Epidemiological surveys and molecular studies have indicated that infection of human papillomavirus (HPV)itself is necessary butinsufficient for completing transformation of the human epithelial cells in vivo to lead to differentcancers. Mounting evidence exists that HPV E6/E7 oncoproteins exactly alter thecellular and molecular events in their transformed cells to induce cancers through a phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway.ThePI3K/Akt/mTOR signalingpathwayis,nonetheless, of central importance, which tightly modulates many cellular events that occur in cells to lead them to be cancerous under the action of oncogenic factors. The cancinogenicrolesof the PI3K/Akt/mTOR signalings in HPV-induced cancers are generally regulated by differentupstream signaling molecules such as upstream receptor tyrosine kinases. In this article, we review the regulatory roles of four major upstream signaling molecules (growth factor receptor, notch receptor, Ras and PI3KCAgenes) in PI3K/Akt/mTOR pathway to result in mutation or amplification of the major elements in the pathway to confer oncogenicity in HPV-immortalized epithelial cells and various transformed phenotypes


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Article Details

Volume: 21
First Page: 1
Last Page: 1
Page Count: 1
DOI: 10.2174/0929867321666140414101528
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