Towards a Poly-Functional Synthetic-Antimalarial Vaccine: Incorporating Non-Natural Elements into Artificially-Made Peptides for Mimicking Functional Pathogen Ligand Structures Representing New Site-Directed Vaccine Components

ISSN: 1875-631X (Online)
ISSN: 1573-3955 (Print)


Volume 10, 2 Issues, 2014


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Current Immunology Reviews

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Editor-in-Chief:
Cecil Czerkinsky
Institut de Pharmacologie Moleculaire et Cellulaire
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Towards a Poly-Functional Synthetic-Antimalarial Vaccine: Incorporating Non-Natural Elements into Artificially-Made Peptides for Mimicking Functional Pathogen Ligand Structures Representing New Site-Directed Vaccine Components

Author(s): Jose Manuel Lozano and Manuel Elkin Patarroyo

Affiliation: Biocatalysis Department, Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No. 26-20, ZC 020304, Bogotá, Colombia.

Abstract

The molecular basis for obtaining novel anti-malarial vaccine candidates depends on a considered selection of antigenic peptides, mainly derived from Plasmodium antigens’ non-polymorphic regions. Since such targeted-molecules are poorly immunogenic when tested as vaccine components, they usually have to be modified to overcome their immunological phenotype. Transition state theory, explaining how peptidases catalyse a given peptide bond breakage, thus led to reduced amide pseudopeptides being proposed as possible mimetics for a transition-state. Stabilising such high-energy molecular stages could become a strategy for inducing antibodies potentially harbouring catalytic properties. Hence, isostere-bond peptido-mimetics represented a rational choice as potential abzyme-inducers and site-directed designed reduced amide pseudopeptides for obtaining peptide-analogues from selected malarial high-binding motifs. This novel family of vaccine candidates has proved to be an efficient functional antibody-inducer, the latter acting as efficient blockers of Plasmodium infection of human and mouse RBCs.

Keywords: Antimalarial vaccine, catalytic antibody, passive immunisation, peptide-bond isostere, peptido-mimetic, pseudopeptide.

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Article Details

Volume: 9
Issue Number: 4
First Page: 261
Last Page: 275
Page Count: 15
DOI: 10.2174/1573395510666140401180738
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