Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections

ISSN: 1875-631X (Online)
ISSN: 1573-3955 (Print)

Volume 11, 2 Issues, 2015

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Current Immunology Reviews

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Cecil Czerkinsky
Institut de Pharmacologie Moleculaire et Cellulaire
660 Route des Lucioles
Valbonne, 06560

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Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections

Current Immunology Reviews, 9(3): 157-168.

Author(s): Kathryn E. McGovern and Emma H Wilson.

Affiliation: School of Medicine, Division of Biomedical Sciences, University of California, Riverside, CA, 92521- 0129, USA.


Parasites are diverse eukaryotic pathogens that can have complex life cycles. Their clearance, or control within a mammalian host requires the coordinated effort of the immune system. The cell types recruited to areas of infection can combat the disease, promote parasite replication and survival, or contribute to disease pathology. Location and timing of cell recruitment can be crucial. In this review, we explore the role chemokines play in orchestrating and balancing the immune response to achieve optimal control of parasite replication without promoting pathology.


CCL21, CCR7, cell trafficking, chemokine, parasite, Toxoplasma.

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Article Details

Volume: 9
Issue Number: 3
First Page: 157
Last Page: 168
Page Count: 12
DOI: 10.2174/1573395509666131217000000

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