Myocardial Ischemia/Reperfusion Injury: Potential of TRPV1 Agonists as Cardioprotective Agents

ISSN: 2212-4063 (Online)
ISSN: 1871-529X (Print)


Volume 14, 3 Issues, 2014


Download PDF Flyer




Cardiovascular & Hematological Disorders-Drug Targets

Formerly: Current Drug Targets - Cardiovascular & Hematological Disorders

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Garry X. Shen
University of Manitoba
Winnipeg, MB
Canada


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Myocardial Ischemia/Reperfusion Injury: Potential of TRPV1 Agonists as Cardioprotective Agents

Author(s): Praveen Vemula, Bikki Gautam, George S. Abela and Donna H. Wang

Affiliation: Division of Nanomedicine and Molecular Intervention, Department of Medicine, B316 Clinical Center, Michigan State University, East Lansing, MI 48824, USA.

Abstract

Myocardial Ischemia/Reperfusion (I/R) induced injury has widespread detrimental effects partially negating the benefits obtained from early revascularization in Acute Myocardial Infarction. Various complex mechanisms contribute to I/R injury and different agents targeting those specific mechanisms are being studied. Despite continued research and widespread interest, none of them have become incorporated into everyday practice. The TRPV1 (transient receptor potential vanilloid 1) channel is a non selective cation channel predominantly expressed in sensory neurons with the nerve fibers innervating the heart and blood vessels. Multiple studies have demonstrated the importance of the activation of TRPV1 and subsequent release of sensory neurotransmitters in cardioprotection. This review focuses on the role of TRPV1 in prevention of cardiac I/R injury, the work that has been done so far and future implications for TRPV1 agonists as cardioprotective agents.

Keywords: Agonist, cardioprotection, Ischemia/Reperfusion, myocardium, TRPV1.

Download Free Rights and Permissions

  
  



Article Details

Volume: 14
Issue Number: 1
First Page: 71
Last Page: 78
Page Count: 8
DOI: 10.2174/1871529X13666131129103759
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science