Lappaconitine: Influence of Halogen Substituent on the Antiarrhythmic Activity

ISSN: 1875-6182 (Online)
ISSN: 1871-5257 (Print)


Volume 12, 3 Issues, 2014


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Cardiovascular & Hematological Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Cardiovascular & Hematological Agents

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Debabrata Mukherjee
Department of Internal Medicine Texas Tech University
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Lappaconitine: Influence of Halogen Substituent on the Antiarrhythmic Activity

Author(s): A. O. Bryzgalov, V. E. Romanov, T. G. Tolstikova and E. E. Shults

Affiliation: Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Prosp. Akad. Lavrent`eva, 630090 Novosibirsk, Russian Federation.

Abstract

The current paper presents research results related to antiarrhythmic activity of halogen-containing derivatives of lappaconitine. Lappaconitine derivatives with iodine, chlorine or bromine substituting the anthranilate moiety at C-5` position were shown in vivo and in vitro to exhibit a more (Br, I) or less (Cl) pronounced antiarrhythmic activity in the models of calcium chloride- and adrenaline-induced arrhythmias as compared with the reference compound lappaconitine. The intensity of antiarrhythmic action depending on halogen substituent was found to be expressed by the following order: Cl < I < Br.

Keywords: Arrhythmia, lappaconitine, halogen-containing lappaconitine derivatives.

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Article Details

Volume: 11
Issue Number: 3
First Page: 211
Last Page: 217
Page Count: 7
DOI: 10.2174/18715257113119990083
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