Gene Therapy: The Role of Cytoskeleton in Gene Transfer Studies Based on Biology and Mathematics

ISSN: 1566-5232 (Print)
ISSN: 1875-5631 (Online)


Volume 14, 6 Issues, 2014


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Editor-in-Chief:
Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France


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Gene Therapy: The Role of Cytoskeleton in Gene Transfer Studies Based on Biology and Mathematics

Author(s): Maria G. Notarangelo, Roberto Natalini and Emanuela Signori

Affiliation: Laboratory of Molecular Pathology and Experimental Oncology, CNR-IFT, via Fosso del Cavaliere 100, 00133, Rome, Italy.

Abstract

Gene therapy is a promising approach for treating a wide range of human pathologies such as genetic disorders as well as diseases acquired over time. Viral and non-viral vectors are used to convey sequences of genes that can be expressed for therapeutic purposes. Plasmid DNA is receiving considerable attention for intramuscular gene transfer due to its safety, simplicity and low cost of production. Nevertheless, strategies to improve DNA uptake into the nucleus of cells for its expression are required. Cytoskeleton plays an important role in the intracellular trafficking. The mechanism regulating this process must be elucidated. Here, we propose a new methodological approach based on the coupling of biology assays and predictive mathematical models, in order to clarify the mechanism of the DNA uptake and its expression into the cells. Once these processes are better clarified, we will be able to propose more efficient therapeutic gene transfer protocols for the treatment of human patients.

Keywords: Gene therapy, intracellular transport, mathematical models, microtubules, plasmid DNA.

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Article Details

Volume: 14
Issue Number: 2
First Page: 121
Last Page: 127
Page Count: 7
DOI: 10.2174/1566523214666140305223251
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