Study on the Effect of HPMC on Compression Coated Floating Pulsatile Delivery of Bisoprolol

ISSN: 2212-3903 (Online)
ISSN: 1574-8855 (Print)


Volume 9, 4 Issues, 2014


Download PDF Flyer




Current Drug Therapy

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Stefano Palomba
Obstetrics and Gynecology Unit
Institute for Hospitalization and Care Scientific
Emilia
Italy


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Study on the Effect of HPMC on Compression Coated Floating Pulsatile Delivery of Bisoprolol

Author(s): Swati Jagdale, Nilesh Bari, Bhanudas Kuchekar and Aniruddha Chabukswar

Affiliation: Department of Pharmaceutics MAEER’s Maharashtra Institute of Pharmacy Pune- 411 038, Maharashtra India.

Abstract

The present work aimed to develop and study the effect of HPMC on compression-coated floating - pulsatile delivery of Bisoprolol. Inner core tablet contains bisoprolol and a super disintegrant. Outer shell contains HPMC K4M and HPMC K100M as erodible layer along with a gas generating agent. Compression-coated tablet of bisoprolol with 120mg HPMC K4M (B2) showed a lag time of 3.40±0.1 hrs with 99.81% drug release. Whereas 110mg HPMC K100M (B5) showed a lag period 4.0±0.1 hrs with 98.91% drug release. A 32 factorial design was applied. HPMC K4M CR and K100M were independent variables whereas drug release, lag time at 4 hrs and swelling index were dependent variables. To understand the interaction of independent variables on dependent variables three dimensional surface response plots were drawn. The responses exhibited by batch F4 (55 mg HPMC K4M and 65 mg K100M) showed lag time 4.20 hrs following the sigmoidal release pattern. Optimizated batch F4 gave good in-vitro in -vivo correlation.

Keywords: Bisoprolol, compression, floating tablet, HPMC, lag time, pulsatile drug delivery system

Purchase Online Rights and Permissions

  
  



Article Details

Volume: 9
First Page: 1
Last Page: 11
Page Count: 11
DOI: 10.2174/1574885509666140115213810
Advertisement

Related Journals



Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science