Development and Optimization of Troxipide Floating Delivery for Treatment of Peptic Ulcer

ISSN: 2212-3903 (Online)
ISSN: 1574-8855 (Print)


Volume 9, 4 Issues, 2014


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Editor-in-Chief:
Stefano Palomba
Obstetrics and Gynecology Unit
Institute for Hospitalization and Care Scientific
Emilia
Italy


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Development and Optimization of Troxipide Floating Delivery for Treatment of Peptic Ulcer

Author(s): Swati C. Jagdale, Shraddha B. Kamble, Bhanudas S. Kuchekar and Aniruddha R. Chabukswar

Affiliation: Department of Pharmaceutics, MAEER’s Maharashtra Institute of Pharmacy, MIT Campus, S.No. 124, Kothrud, Pune- 411 038, Maharashtra, India.

Abstract

Purpose: The objective of the present work was to develop a site specific gastro-retentive floating tablet of Troxipide for the treatment of peptic ulcer. Troxipide is a novel anti-ulcer agent having an elimination half-life of 7.4 hrs and mainly absorbed from the gastrointestinal tract.

Methods: 32 factorial design was applied. Dependant variables were swelling index, hardness and % drug release. Pluronic acid F127 and HPMC K 15M were used as rate controlled polymer. Optimized formulations were evaluated for physical characteristics, buoyancy, buoyancy lag-time, drug content, in- vitro drug release, floating behavior and in-vivo X-ray study.

Results: Formulation H5 (20% Pluronic acid F127 and 78% HPMC K 15M) showed a floating lag time 60 ±2 sec with a desired controlled release profile over a period of 10 hrs. FTIR and DSC studies confirmed no chemical interactions. In-vivo X-ray study for optimized formulations showed gastro retention for 6 hrs.

Conclusion: Results demonstrate feasibility of development of gastroretentive floating tablet of Troxipide.


Keywords: Factorial, gastro-retentive, peptic ulcer, troxipide, variables.

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Article Details

Volume: 9
Issue Number: 2
First Page: 83
Last Page: 92
Page Count: 10
DOI: 10.2174/1574885508666131217003926
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