Microtubule Targeting Agents: A Benchmark in Cancer Therapy

ISSN: 2212-3903 (Online)
ISSN: 1574-8855 (Print)


Volume 9, 4 Issues, 2014


Download PDF Flyer




Current Drug Therapy

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Stefano Palomba
Obstetrics and Gynecology Unit
Institute for Hospitalization and Care Scientific
Emilia
Italy


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Microtubule Targeting Agents: A Benchmark in Cancer Therapy

Author(s): Verma Nitika and Khatri Kapil

Affiliation: ISF College of Pharmacy, Ferozepur GT Road, Moga, Punjab-142001, India.

Abstract

The treatment of many diseases owes much to the important medicines that have been derived from plants, cancer is no exception. Cancer is a class of diseases characterized by out-of-control cell growth. Researchers have developed many agents which have shown brilliant therapeutic results against cancerous cells out of which the microtubule-targeting agents (MTAs) have made significant contributions to cancer therapy over the past 50 years. These dynamic tubulin structures can be targeted for the treatment of cancer due to their critical role in mitosis and other cellular processes. MTAs cause stabilisation (MSAs) or depolymerisation (MDAs) of the microtubules and hence result in apoptosis. This therapy has been frequently used in the treatment of advanced ovarian, breast, lung, head and neck, and prostate cancer, and is increasingly being used in early stage disease. Taxanes (e.g. paclitaxel, docetaxel) and epothilones (e.g. ixabepilone) are microtubule-targeting agents, which disrupt cellular processes and induce apoptosis. Nocodazole, Chamaecypanone C, Discodermolide, Noscapine, Laulimalide, and Eribulin are similar natural agents with convincing therapeutic efficacy in this field. Collectively these findings suggest mechanisms and therapies by which growth conditions may contribute to resistance to rapid killing by microtubule-disrupting drugs.

Keywords: Apoptosis, cancer, depolymerisation, microtubule targeting agents, stabilization.

Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 8
Issue Number: 3
First Page: 189
Last Page: 196
Page Count: 8
DOI: 10.2174/15748855113086660011
Advertisement

Related Journals



Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science