Tuberculosis: a therapeutically neglected disease

ISSN: 2212-3903 (Online)
ISSN: 1574-8855 (Print)

Volume 10, 2 Issues, 2015

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Stefano Palomba
Obstetrics and Gynecology Unit
Institute for Hospitalization and Care Scientific

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Tuberculosis: a therapeutically neglected disease

Author(s): Paula A. Abreu, Cid A. Medeiros, Julio C. Borges, Alice M. R. Bernardino, Carlos R. Rodrigues and Helena C. Castro

Affiliation: Department of Cell and Molecular Biology Institute of Biology Universidade Federal Fluminense Av-Barros Terrra s / n, Valonguinho, Niterói, RJ Brazil.


Tuberculosis is a neglected disease caused by Mycobacterium tuberculosis. Some evidence suggests its existence since thousands of years and today it still represents a public health problem. Current treatment presents serious problems such as adverse effects, high cost, long term, besides the emergence of resistant strains. Therefore the search for new antimicrobials is still in need. In this work we reviewed tuberculosis treatment as well as the synthesis of the current drugs and new synthetic derivatives that have been developed against M. tuberculosis. In this context we explored the medicinal chemistry and molecular modeling strategies as important tools to guide the rational design and synthesis of novel chemotherapeutic agents for use in tuberculosis.

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Article Details

Volume: 8
First Page: 1
Page Count: 1
DOI: 10.2174/15748855113089990006

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