Targets for Medical Therapy to Limit Abdominal Aortic Aneurysm Progression

ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)

Volume 16, 14 Issues, 2015

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Current Drug Targets

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Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Targets for Medical Therapy to Limit Abdominal Aortic Aneurysm Progression

Current Drug Targets, 15(9): 860-873.

Author(s): Theophilus I. Emeto, Sai-Wang Seto and Jonathan Golledge.

Affiliation: Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University Townsville, QLD 4811, Australia.


Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Most AAAs are asymptomatic and screening programs have been introduced to identify AAAs at an early stage in some countries. There is currently no accepted therapy for early stage or small AAAs, which are frequently identified by such programs. In this review, we discuss work underway to identify targets for medical treatments to limit progression of small AAAs. Specifically we discuss studies, which have examined the potential of targeting inflammation, proteolysis, the renin-angiotensin system, the coagulation system and sex hormones as approaches to limiting AAA pathogenesis. As yet, none of the treatment targets have translated into an agent, which can effectively reduce AAA progression in clinical practice.


Abdominal aortic aneurysm, animal models, clinical trial, pharmacotherapy.

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Article Details

Volume: 15
Issue Number: 9
First Page: 860
Last Page: 873
Page Count: 14
DOI: 10.2174/1389450115666140804155036
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