New Use for Old Drugs? Prospective Targets of Chloroquines in Cancer Therapy

ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)


Volume 15, 14 Issues, 2014


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Editor-in-Chief:
Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA


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New Use for Old Drugs? Prospective Targets of Chloroquines in Cancer Therapy

Author(s): Spiros Vlahopoulos, Elena Critselis, Ioannis F. Voutsas, Sonia A. Perez, Maria Moschovi, Constantin N. Baxevanis and George P. Chrousos

Affiliation: Horemio Research Institute, First Department of Pediatrics, University of Athens Medical School, “Aghia Sophia” Children’s Hospital, Thivon & Levadias, 11527 Goudi, Athens, Greece.

Abstract

During the last decade research is gradually repositioning the antimalarial drug chloroquine, and certain related quinoline derivatives, as anticancer agents. Chloroquine and hydroxychloroquine, in particular, have relatively wellcharacterized toxicity profiles due to several decades of use for treatment of malaria. Previously published review articles provide an excellent overview of the diversity of chloroquine effects on cancer cells, both in the cell culture as well as on human tumors grafted into mice; and an account of the increasing pace of incorporation of hydroxychloroquine in combination treatment schemes for clinical studies. In this review we present some features that are common between cancers that are sensitive to quinoline derivatives, in particular features that are amenable to pharmaceutical intervention.

Keywords: Chloroquine, cancer, autophagy, lysosome, immunity.

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Article Details

Volume: 15
Issue Number: 9
First Page: 843
Last Page: 851
Page Count: 9
DOI: 10.2174/1389450115666140714121514
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