Genomic identification of potential targets unique to Candida albicans for the discovery of antifungal agent

ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)


Volume 15, 14 Issues, 2014


Download PDF Flyer




Current Drug Targets

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 52nd of 254 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 3.597
5 - Year: 3.558

Genomic identification of potential targets unique to Candida albicans for the discovery of antifungal agent

Author(s): Himanshu Tripathi, Suaib Luqman, Abha Meena and Feroz Khan

Affiliation: Department of Metabolic and Structural Biology, CSIR-Central Institute of Medicinal & Aromatic Plants, Lucknow- 226015, India

Abstract

Despite of modern antifungal therapy, the mortality rates for invasive infection with human fungal pathogen Candida albicans is up to 40%. Studies suggest that drug resistance in the three most common species of human fungal pathogens viz., C. albicans, Aspergillus fumigatus (causes mortality rate up to 90%) and Cryptococcus neoformans (causes mortality rate up to 70%) are due to developing mutation in the targeted enzymes or through high expression of drug transporter genes. Drug resistance in human fungal pathogens has led to an imperative need for identification of new targets unique to fungal pathogens. In the present study, we have used a comparative genomics approach to find out potential target proteins unique to C. albicans, an opportunistic fungus responsible for severe infection in immuno compromised human. Interestingly many target proteins of existing antifungal agents showed orthologs in human cells. To identify unique proteins, we have compared proteome of C. albicans [SC5314] i.e., 14,633 total proteins retrieved from RefSeq database of NCBI, USA with proteome of human and non-pathogenic yeast Saccharomyces cerevisiae. Results showed that 4,568 proteins were identified unique to C. albicans in compared to human and later when these unique proteins compared with S. cerevisiae proteome, finally 2,161 proteins were identified as unique proteins and after removing repeats total 1,618 unique proteins (42 functionally known, 1,566 hypothetical and 10 unknown) are selected as potential antifungal drug targets unique to C. albicans


Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 14
First Page: 1
Page Count: 1
DOI: 10.2174/13894501113146660225
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science