Clozapine Safety, 40 Years Later

ISSN: 2212-3911 (Online)
ISSN: 1574-8863 (Print)


Volume 9, 3 Issues, 2014


Download PDF Flyer




Current Drug Safety

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Dr. Seetal Dodd
University of Melbourne
Geelong, 3220
Australia


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Clozapine Safety, 40 Years Later

Author(s): Michele Raja and Silvia Raja

Affiliation: via Prisciano 26, 00136 – Roma, Italy

Abstract

Clozapine is, and will remain in the coming years, an irreplaceable drug in psychiatry which has elective indication in treatment-resistant schizophrenia, suicide risk in schizophrenia spectrum disorders, aggressiveness or violence in psychiatric patients, psychosis in Parkinson’s disease, prevention and treatment of tardive dyskinesia. Unfortunately, the drug is largely underused for many and serious side effects. Only a good knowledge of these side effects and of the main strategies to prevent their occurrence or minimize their impact can allow overcoming the under-utilization of this valuable therapy.

The article describes the clinical and epidemiological features of the non-motor side effects of clozapine including blood dyscrasias, constipation, diabetes, enuresis, fever, hepatitis, hypersalivation, ileus, myocarditis, nephritis, priapism, seizures, serositis, weight gain and metabolic syndrome. The paper suggests several strategies, supported by scientific evidence, in the management of these side effects. The neuropsychiatric side effects of clozapine are not discussed in this review


Keywords: Clozapine, schizophrenia, side effects, treatment

Purchase Online Rights and Permissions

Article Details

Volume: 9
First Page: 1
Last Page: 34
Page Count: 34
DOI: 10.2174/1574886309666140428115040
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science