Hyponatraemia Associated with Trimethoprim Use

ISSN: 2212-3911 (Online)
ISSN: 1574-8863 (Print)

Volume 10, 3 Issues, 2015

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Current Drug Safety

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Dr. Seetal Dodd
University of Melbourne
Geelong, 3220

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Hyponatraemia Associated with Trimethoprim Use

Current Drug Safety, 9(1): 79-82.

Author(s): Kareeann Sok Fun Khow and Tuck Yean Yong.

Affiliation: Department of General Medicine, Flinders Medical Centre, Flinders Drive, Bedford Park, South Australia 5042, Australia.


Trimethoprim (TMP) is a commonly prescribed antibiotic with few adverse effects. However on rare occasions, TMP is associated with electrolyte disturbances. As seen in our three patients, TMP can be associated with symptomatic hyponatraemia which required hospitalization. In one of these patients, hyperkalaemia and type 4 renal tubular acidosis were also present. These electrolyte and acid-base disorders were corrected after discontinuation of TMP. A small number of patients with TMP-induced electrolyte imbalances have been reported in the English-language medical literature to date but mostly with the use of TMP in combination with sulfamethoxazole. In association with TMP use, hyperkalaemia has been more commonly reported than hyponatraemia. These changes in sodium and potassium balance are thought to be related to TMP inhibiting sodium ion influx via the epithelial sodium channel in the cortical collecting duct. The association between symptomatic hyponatraemia and TMP emphasizes the need to evaluate electrolytes in patients presenting with clinical change after commencing on this drug.


Electrolyte disorders, hyponatraemia, sodium, trimethoprim, trimethoprim-sulfamethoxazole.

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Article Details

Volume: 9
Issue Number: 1
First Page: 79
Last Page: 82
Page Count: 4
DOI: 10.2174/1574886308666131230160847

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