Gold Nanoparticle-Based Drug Delivery Platform for Antineoplastic Chemotherapy

ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)


Volume 15, 10 Issues, 2014


Download PDF Flyer




Current Drug Metabolism

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 101th of 291 in Biochemistry & Molecular Biology
  • 54th of 254 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Chandra Prakash
Department of Drug Metabolism and Pharmacokinetics Biogen Idec Cambridge
MA
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 3.487
5 - Year: 4.205

Gold Nanoparticle-Based Drug Delivery Platform for Antineoplastic Chemotherapy

Author(s): Juan-Juan Liang, Ying-Ying Zhou, Jun Wu and Ya Ding

Affiliation: Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China.

Abstract

Gold nanoparticles (AuNPs) have demonstrated increasingly wide applications in drug delivery due to their unique physicochemical and optical properties as well as low toxicity. Compared to the organic nanocarriers for therapeutic agents, AuNPs have shown superior performance as drug delivery vectors, including the inert nature, well-developed synthesis strategies, tunable size, and flexible and easy surface modification with various chemical and biological molecules. In this review, we emphasize on the applications of AuNPs in the aspect of improving pharmaceutical property and therapeutic efficacy of drugs, especially those covalently and noncovalently connected to the surface of AuNPs. Acting as a solid core to link drugs and their derivatives, AuNPs provide the nano-prodrug system with compressed size, high loading efficiency, three-dimension structure, and enhanced cellular uptake capability. With the intensive and systematical investigation of the drug-connected AuNPs, several important issues will become the hot but emergent topics for future research in this field, such as the toxicity in live human subjects, ultimate destination, and possible pathways and mechanisms for their absorption, circulation, distribution, metabolism, and excretion.

Keywords: Conjugates, drug delivery system, gold nanoparticles, toxicity.

Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 15
Issue Number: 6
First Page: 620
Last Page: 631
Page Count: 12
DOI: 10.2174/1389200215666140605131427
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science