A 30-years Review on Pharmacokinetics of Antibiotics: Is the Right Time for Pharmacogenetics?

ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)

Volume 18, 12 Issues, 2017

Download PDF Flyer

Current Drug Metabolism

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 125th of 289 in Biochemistry & Molecular Biology
  • 82nd of 254 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

Michael Sinz
Bristol Myers Squibb
Wallingford, CT

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.847
5 - Year: 3.222

A 30-years Review on Pharmacokinetics of Antibiotics: Is the Right Time for Pharmacogenetics?

Current Drug Metabolism, 15(6): 581-598.

Author(s): Lorena Baietto, Silvia Corcione, Giovanni Pacini, Giovanni Di Perri, Antonio D’Avolio and Francesco Giuseppe De Rosa.

Affiliation: Department of Medical Sciences, University of Turin, Infectious Diseases at Amedeo di Savoia Hospital, Corso Svizzera 164, 10149. Turin, Italy.


Drug bioavailability may vary greatly amongst individuals, affecting both efficacy and toxicity: in humans, genetic variations account for a relevant proportion of such variability. In the last decade the use of pharmacogenetics in clinical practice, as a tool to individualize treatment, has shown a different degree of diffusion in various clinical fields.

In the field of infectious diseases, several studies identified a great number of associations between host genetic polymorphisms and responses to antiretroviral therapy. For example, in patients treated with abacavir the screening for HLA-B*5701 before starting treatment is routine clinical practice and standard of care for all patients; efavirenz plasma levels are influenced by single nucleotide polymorphism (SNP) CYP2B6-516G>T (rs3745274). Regarding antibiotics, many studies investigated drug transporters involved in antibiotic bioavailability, especially for fluoroquinolones, cephalosporins, and antituberculars. To date, few data are available about pharmacogenetics of recently developed antibiotics such as tigecycline, daptomycin or linezolid. Considering the effect of SNPs in gene coding for proteins involved in antibiotics bioavailability, few data have been published.

Increasing knowledge in the field of antibiotic pharmacogenetics could be useful to explain the high drug inter-patients variability and to individualize therapy. In this paper we reported an overview of pharmacokinetics, pharmacodynamics, and pharmacogenetics of antibiotics to underline the importance of an integrated approach in choosing the right dosage in clinical practice.


Metabolism, pharmacology, pharmacogenomic, single nucleotide polymorphism (SNP), tailored therapy, therapeutic drug monitoring (TDM), transporter, treatment.

Download Free Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 15
Issue Number: 6
First Page: 581
Last Page: 598
Page Count: 18
DOI: 10.2174/1389200215666140605130935

Related Journals

Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science