Prediction by Pharmacogenetics of Safety and Efficacy of Non-Steroidal Anti- Inflammatory Drugs: A Review

ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)


Volume 15, 10 Issues, 2014


Download PDF Flyer




Current Drug Metabolism

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 101th of 291 in Biochemistry & Molecular Biology
  • 54th of 254 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Chandra Prakash
Department of Drug Metabolism and Pharmacokinetics Biogen Idec Cambridge
MA
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 3.487
5 - Year: 4.205

Prediction by Pharmacogenetics of Safety and Efficacy of Non-Steroidal Anti- Inflammatory Drugs: A Review

Author(s): Victoria Rollason, Caroline Flora Samer, Youssef Daali and Jules Alexandre Desmeules

Affiliation: Division of Clinical Pharmacology and Toxicology, University Hospitals of Geneva, Gabrielle-Perret- Gentil Street 4, 1211 Geneva 14, Switzerland.

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently used drugs, either on prescription or over-thecounter (OTC). Their daily dosage is based on randomised controlled trials and an empirical clinical assessment of their efficacy and toxicity that allows dose adjustment. The individual response can however be altered by environmental and genetic pharmacokinetic and pharmacodynamic factors. This review summarizes the available pharmacogenetic data that explains part of the variability in response and occurrence of adverse drug reactions to NSAIDs treatment, with a thorough focus on CYP2C9, uridine diphosphate glucuronosyltransferases (UGTs) and cyclooxygenases (COX1 and COX2). Other polymorphisms that are currently being studied and could also explain the interindividual variability in the efficacy and safety of NSAIDs will also be considered.

Keywords: COX, CYP2C8, CYP2C9, genetic polymorphism, NSAIDs, PTGS, UDP glucuronsyltransferases, UGT.

Download Free Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 15
Issue Number: 3
First Page: 326
Last Page: 343
Page Count: 18
DOI: 10.2174/1389200215666140202214454
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science