Nicotinic Acid and its Derivatives: Synthetic Routes, Crystal Forms and Polymorphs

ISSN: 1875-6220 (Online)
ISSN: 1570-1638 (Print)

Volume 12, 4 Issues, 2015

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Current Drug Discovery Technologies

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Vladimir P. Torchilin
Department of Pharmaceutical Science Center
for Pharmaceutical Biotechnology and Nanomedicine
Northeastern University
Boston, MA 02115

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Nicotinic Acid and its Derivatives: Synthetic Routes, Crystal Forms and Polymorphs

Current Drug Discovery Technologies, 11(2): 97-108.

Author(s): Pan-Pan Zhou, Xiao-Bo Sun and Wen-Yuan Qiu.

Affiliation: Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 222 South Tianshui Road, 730000, Lanzhou, People's Republic of China.


Nicotinic acid is a well-known pharmaceutical in the vitamin B group that has attracted great interest in the past decades due to its significant importance in the treatment of the human diseases like pellagra. Also, nicotinic acid derivatives have been devoted to much attention due to their different pharmaceutical effects in the treatment of diseases. In view of this, the developments of nicotinic acid and its derivatives including their synthetic methods by using different substrates, and their structural modifications (e.g., substitution of one or more positions of pyridyl ring or acid) were reviewed in details. Drug molecules like nicotinic acid and its derivatives may exist in more than one crystal form in its solid state, known as polymorphs. Different polymorphs have different dissolution rates and aqueous solubility. Therefore, we reviewed structures of different crystal forms of nicotinic acid and its derivatives.


Crystal forms, derivatives, nicotinic acid, pharmaceutical, polymorphs.

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Article Details

Volume: 11
Issue Number: 2
First Page: 97
Last Page: 108
Page Count: 12
DOI: 10.2174/1570163811666140225152610

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