Nicotinic Acid and its Derivatives: Synthetic Routes, Crystal Forms and Polymorphs

ISSN: 1875-6220 (Online)
ISSN: 1570-1638 (Print)

Volume 14, 4 Issues, 2017

Download PDF Flyer

Current Drug Discovery Technologies

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Vladimir P. Torchilin
Department of Pharmaceutical Science Center
for Pharmaceutical Biotechnology and Nanomedicine
Northeastern University
Boston, MA 02115

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Nicotinic Acid and its Derivatives: Synthetic Routes, Crystal Forms and Polymorphs

Current Drug Discovery Technologies, 11(2): 97-108.

Author(s): Pan-Pan Zhou, Xiao-Bo Sun and Wen-Yuan Qiu.

Affiliation: Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 222 South Tianshui Road, 730000, Lanzhou, People's Republic of China.


Nicotinic acid is a well-known pharmaceutical in the vitamin B group that has attracted great interest in the past decades due to its significant importance in the treatment of the human diseases like pellagra. Also, nicotinic acid derivatives have been devoted to much attention due to their different pharmaceutical effects in the treatment of diseases. In view of this, the developments of nicotinic acid and its derivatives including their synthetic methods by using different substrates, and their structural modifications (e.g., substitution of one or more positions of pyridyl ring or acid) were reviewed in details. Drug molecules like nicotinic acid and its derivatives may exist in more than one crystal form in its solid state, known as polymorphs. Different polymorphs have different dissolution rates and aqueous solubility. Therefore, we reviewed structures of different crystal forms of nicotinic acid and its derivatives.


Crystal forms, derivatives, nicotinic acid, pharmaceutical, polymorphs.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 11
Issue Number: 2
First Page: 97
Last Page: 108
Page Count: 12
DOI: 10.2174/1570163811666140225152610
Price: $58
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

Related Journals

Related eBooks

Webmaster Contact: Copyright © 2017 Bentham Science