Single Amino Acid Repeats Connect Viruses to Neurodegeneration

ISSN: 1875-6220 (Online)
ISSN: 1570-1638 (Print)


Volume 11, 4 Issues, 2014


Download PDF Flyer




Current Drug Discovery Technologies

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Vladimir P. Torchilin
Department of Pharmaceutical Science Center
for Pharmaceutical Biotechnology and Nanomedicine
Northeastern University
Boston, MA 02115
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Single Amino Acid Repeats Connect Viruses to Neurodegeneration

Author(s): Guglielmo Lucchese and Darja Kanduc

Affiliation: Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona, 4, 70125, Bari, Italy.

Abstract

We report on a high level of octapeptide matching between HCV, HIV-2, MPV, MUV, EBV, HHV-6, and CMV, and human brain antigens that, when altered, have been specifically associated with neuropathologies such as amyotrophic lateral sclerosis, spinocerebellar ataxia, frontotemporal degeneration, Huntington disease, Parkinson disease, cognitive impairment, aphasia and oculomotor apraxia. Quantitatively, the extent of the viral octapeptide sharing with neurodegeneration- associated proteins is in excess when analyzed in a stochastic expectation context. Qualitatively, two main features characterize the peptide matching: 1) many common sequences are single amino acid repeats, and 2) mostly, the shared octapeptides are part of experimentally validated epitopes, thus suggesting an immune crossreactive potential of the viral peptides shared with brain antigens involved in neurodegeneration. The present study may have relevance for peptidebased therapeutic approaches to block potential autoimmune crossreactions in neurological diseases and dysfunctional behavior.

Keywords: Viral infections, neurodegeneration, peptide sharing, immune crossreactivity.

Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 11
Issue Number: 3
First Page: 214
Last Page: 219
Page Count: 6
DOI: 10.2174/1570163811666140212112300
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science