Potent Phosphatidylinositol 3-Kinase Inhibitors and Their Biology

ISSN: 1875-6220 (Online)
ISSN: 1570-1638 (Print)

Volume 12, 4 Issues, 2015

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Current Drug Discovery Technologies

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Vladimir P. Torchilin
Department of Pharmaceutical Science Center
for Pharmaceutical Biotechnology and Nanomedicine
Northeastern University
Boston, MA 02115

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Potent Phosphatidylinositol 3-Kinase Inhibitors and Their Biology

Current Drug Discovery Technologies, 11(2): 113-126.

Author(s): Mukesh Chandra Joshi, Krishan Kumar and Vikrant Kumar.

Affiliation: Department of Chemistry, Motilal Nehru College, University of Delhi, Delhi-110021, India.


The Phosphoinositide 3-kinase (PI3k) is an important regulator of intracellular signalling pathways, like cell proliferation, migration, survival, and angiogenesis upon activation by growth factor or receptors. The PI3k’s pathway is frequently up-regulated in human cancers, thus inhibition of PI3k’s is a promising approach for cancer therapy. Many potent PI3k’s inhibitors have been reported so far and few of them are in clinical trial like GDC-0941, BGT-226, AZD-6482 and others are natural products etc.


Clinical trial, glioblastoma cell lines, leukemia and lymphoma cell lines, phosphoinositide 3-kinase, proliferation, tumor inhibitors.

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Article Details

Volume: 11
Issue Number: 2
First Page: 113
Last Page: 126
Page Count: 14
DOI: 10.2174/1570163810666131229130207

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