Surface Modified Nanoparticulate Carrier Constructs for Oral Mucosal Vaccine Delivery

ISSN: 1875-5704 (Online)
ISSN: 1567-2018 (Print)


Volume 11, 6 Issues, 2014


Download PDF Flyer




Current Drug Delivery

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 126th of 254 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Istvan Toth
School of Pharmacy,University of Queensland
Brisbane, 4072
Australia


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.248

Surface Modified Nanoparticulate Carrier Constructs for Oral Mucosal Vaccine Delivery

Author(s): Neeraj Mishra, Devendra Singh, Sandeep Sharma and Ashish Baldi

Affiliation: I.S.F. College of Pharmacy, Ferozpur G.T. Road, NH. 95, Moga (Punjab), India.

Abstract

Mucosal administration of vaccines is one of the most popular approaches to induce desired immunity against various types of antigen and microbial in central as well as peripheral blood and in most external mucosal surfaces. The oral route is a preferred choice over parenteral route for this purpose mainly due to an ease of administration and therefore, for the possibility of covering large population for mass immunization. Different strategies of mucosal vaccination aimed to prevent colony formation and infection by pathogens and block its development. But a major concern with these vaccines is the degradation of protein components in stomach due to physiological conditions and gastric enzymes. Therefore, surface modified nanoparticles offer a better and stable alternative for efficient delivery and better activation of required immune responses. Natural and synthetic polymers are used to prepare nanoparticulate carrier systems for the development of oral mucosal vaccines. Amongst these, biodegradable polymers based nano-particulate carriers have been explored extensively for the development of delivery systems. Present review summarizes possible approaches and mechanisms for the systemic immunization by oral vaccines and critically discusses various polymers used, different strategies of surface modification to achieve targeting of antigen loaded nanoparticulate carrier at cellular level that are essentially required for a successful mucosal vaccination approach, and future prospects of nanoparticulate system as adjutants in oral mucosal vaccination.




Keywords: Biodegradable polymers, lectins, mucosal immunization, nanocarriers, nanoparticles, oral vaccines.

Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 11
Issue Number: 6
First Page: 729
Last Page: 743
Page Count: 15
DOI: 10.2174/1567201811666140709112040
Advertisement
12th annual Controlled Release Conference

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science