Physical Means of Stratum Corneum Barrier Manipulation to Enhance Transdermal Drug Delivery

ISSN: 1875-5704 (Online)
ISSN: 1567-2018 (Print)


Volume 12, 6 Issues, 2015


Download PDF Flyer




Current Drug Delivery

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Istvan Toth
School of Pharmacy,University of Queensland
Brisbane, 4072
Australia


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 1.478

Physical Means of Stratum Corneum Barrier Manipulation to Enhance Transdermal Drug Delivery



Current Drug Delivery, 12(2): 122-138.

Author(s): Rabinarayan Parhi, Podilam Suresh and Suhasini Patnaik.

Affiliation: Department of Pharmaceutics, GITAM Institute of Pharmacy, GITAM University, Gandhi Nagar Campus, Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India.

Abstract

Since the approval of first transdermal patch (Transderm Scop®) containing scopolamine in 1979, the improvement in systemic drug delivery through skin remains incremental. The traditional methods based on passive diffusion of drug molecules in to the skin are unable to deliver macromolecules, such as peptides, proteins, DNA and vaccines, due to the barrier properties of stratum corneum (SC). During the course of approximately 35 years, the focuses are not only to overcome the above barrier property of the skin but also the safety, accuracy and patient compliance aspect of the traditional methods. The former limitation can be overcome by altering the SC barrier function by different active methods such electrically assisted methods (sonophoresis, iontophoresis, electroporation, magnetophoresis, pressure waves, electron beam irradiation), SC abruption (microneedles, high-velocity jet) and SC removal (tape-stripping, suction, microdermabrasion, ablation). This review summarizes basic principles, mechanisms, advantages, limitations and recent development of above physical techniques along with skin anatomy and drug transport pathways across skin.




Keywords:

Bilipid layer, Cavitation, Microneedle, Permeation, Physical methods, Transdermal drug delivery, Stratum corneum.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 12
Issue Number: 2
First Page: 122
Last Page: 138
Page Count: 17
DOI: 10.2174/1567201811666140515145329
Advertisement
Orphan Drugs and Rare Diseases Conference

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2015 Bentham Science