Invasive and Noninvasive Assessment of Exercise-induced Ischemic Diastolic Response Using Pressure Transducers

ISSN: 1875-6557 (Online)
ISSN: 1573-403X (Print)

Volume 13, 4 Issues, 2017

Download PDF Flyer

Current Cardiology Reviews

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Jian'an Wang
School of Medicine Zhejiang University

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Invasive and Noninvasive Assessment of Exercise-induced Ischemic Diastolic Response Using Pressure Transducers

Current Cardiology Reviews, 11(1): 90-99.

Author(s): Jan Manolas.

Affiliation: Mobile Unit for Diastolic Stress Test, Department of Check Up, Diagnostic & Therapeutic Center of Athens, Hygeia Hospital, Erythrou Stavrou 4 and Kifissias Ave. Maroussi, Athens 151 23, Greece.


Left ventricular (LV) pressure curve shows early high-magnitude changes in the presence of induced ischemia. A dramatic rise in LV and left atrial end-diastolic pressures occurs within seconds to minutes in the presence of ischemia induced by dynamic or handgrip exercise as well as pacing of 38 to 183% and during short coronary balloon occlusion of 32 to 208% of baseline. Changes in relaxation or volumetric filling rate or ejection fraction were significantly less pronounced.

Similar end-diastolic abnormalities occurring mainly in patients with coronary artery disease (CAD) have been shown in noninvasive recordings obtained by pressure transducer placed over the point of maximal LV beat (pressocardiograms). Specifically, the amplitude of the A wave to total excursion of pressocardiogram showed a similar high-magnitude increase after dynamic or handgrip exercise in average by 60 to 142% of baseline; however, changes in pressocardiographic relaxation time indexes were only slightly abnormal. A well-defined “ischemic pattern” of pressocardiographic diastolic changes with handgrip, showed a high prevalence in CAD patients.

The assessment of diastolic changes in the presence of handgrip-inducible ischemia using noninvasive pressure transducers might provide after further studies a simple complementary diagnostic tool to assist in identification of patients with atypical or asymptomatic CAD.


Coronary artery disease, diastolic dysfunction, diagnostics, end-diastolic pressure, isometric handgrip exercise, left ventricular dysfunction, myocardial ischemia, stress testing.

Download Free Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 11
Issue Number: 1
First Page: 90
Last Page: 99
Page Count: 10
DOI: 10.2174/1573403X10666140704111537
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

Related Journals

Related eBooks

Webmaster Contact: Copyright © 2017 Bentham Science