Stage B: What is the Evidence for Treatment of Asymptomatic Left Ventricular Dysfunction?

ISSN: 1875-6557 (Online)
ISSN: 1573-403X (Print)

Volume 11, 4 Issues, 2015

Download PDF Flyer

Current Cardiology Reviews

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Jian'an Wang
School of Medicine Zhejiang University

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Stage B: What is the Evidence for Treatment of Asymptomatic Left Ventricular Dysfunction?

Current Cardiology Reviews, 11(1): 18-22.

Author(s): Brent N. Reed and Carla A Sueta.

Affiliation: Center for Heart & Vascular Care, University of North Carolina, 160 Dental Circle, CB 7075, Chapel Hill, NC 27599-7075, USA.


Although patients with American College of Cardiology / American Heart Association (ACC/AHA) Stage B heart failure, or asymptomatic left ventricular dysfunction (ALVD) are at high risk for developing symptomatic heart failure, few management strategies have been shown to slow disease state progression or improve long-term morbidity and mortality. Of the pharmacologic therapies utilized in patients with symptomatic disease, only angiotensin converting enzyme (ACE) inhibitors (and to a lesser extent, angiotensin receptor blockers, or ARBs) have been shown to improve clinical outcomes among patients with ALVD. Although evidence to support the use of beta blockers in this setting has been primarily derived from retrospective studies or subgroup analyses, they are generally recommended in most patients with ALVD, especially those with ischemic etiology. Statins are associated with improvements in both major adverse cardiovascular events and heart failure events among patients with a history of acute myocardial infarction. Finally, in eligible patients, placement of an automatic implantable cardioverter defibrillator (ICD) has been associated with reduced mortality rates among those with ALVD due to ischemic cardiomyopathy, and some subgroups may derive benefit from cardiac resynchronization therapy or biventricular pacing.


ACE inhibitors, asymptomatic left ventricular dysfunction, beta blockers, device therapy, heart failure, stage B.

Download Free Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 11
Issue Number: 1
First Page: 18
Last Page: 22
Page Count: 5
DOI: 10.2174/1573403X09666131117164352

Related Journals

Webmaster Contact: Copyright © 2015 Bentham Science