Affiliation: State University of São Paulo “Júlio de Mesquita Filho” –UNESP, School of Pharmaceutical Science, Drugs and Medicines Departament, Center of Pharmaceutical Care (NAF), Rodovia Araraquara Jaú Km, 01, 14801-902 Araraquara, SP, Brazil.
Tuberculosis is one of the leading causes of morbidity and mortality worldwide. Current treatment has several challenges, such as multi-drug resistance, extensively drug-resistance and HIV co-infection. Problems related to patients, treatment and health care system also contribute negatively to this panel. This review summarizes the main obstacles causing in the treatment of tuberculosis and discusses several strategies to improve the treatment.