Cardiotonic Steroids in Adaptation to Dietary Salt Intake

ISSN: 2212-3938 (Online)
ISSN: 1574-8847 (Print)

Volume 12, 4 Issues, 2017

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Current Clinical Pharmacology

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Arduino A. Mangoni
Flinders University and Flinders Medical Centre
Adelaide, SA

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Cardiotonic Steroids in Adaptation to Dietary Salt Intake

Current Clinical Pharmacology, 9(3): 298-309.

Author(s): Larry Dial, Jiang Liu and Joseph I Shapiro.

Affiliation: Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701-3655, USA.


For many years the concept relating salt to blood pressure (BP) changes has been debated and the concept of natriuretic hormone eliminating excessive sodium by direct inhibition of Na/K-ATPase has raised controversy. However, a recently discovered Na/K-ATPase signaling function has been widely confirmed and provided a novel mechanism to explain the relationship between sodium and blood pressure. Recently, we have demonstrated that activation of this Na/KATPase signaling function regulates sodium reabsorption in renal proximal tubules (RPTs) to correct sodium retention related volume expansion and BP increase. This mechanism demonstrates that rather than contributing to development and maintenance of hypertension, a properly regulated RPT Na/K-ATPase signaling has a protective effect by stimulating renal sodium excretion. A clear understanding of molecular mechanisms whereby the Na/K-ATPase signaling axis counterbalance volume expansion would have major pathophysiological and therapeutic implications for volume expansion mediated hypertension. In this review, we will focus on the effect of the newly appreciated cardiotonic steroids (CTS)-Na/K-ATPase signaling on RPT-mediated sodium handling by coordinated regulation of the Na/K-ATPase and sodium/proton exchanger isoform 3 (NHE3).


Blood pressure, cardiotonic steroids, Na/K-ATPase signaling, renal function, salt intake.

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Article Details

Volume: 9
Issue Number: 3
First Page: 298
Last Page: 309
Page Count: 12
DOI: 10.2174/1574884708666131111204031
Price: $58

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