UCSF Small Molecule Discovery Center: Innovation, Collaboration and Chemical Biology in the Bay Area

ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)


Volume 17, 10 Issues, 2014


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Combinatorial Chemistry & High Throughput Screening

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Ranking and Category:
  • 23rd of 71 in Chemistry, Applied
  • 47th of 75 in Biochemical Research Methods
  • 152th of 261 in Pharmacology & Pharmacy

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Editor-in-Chief:
Rathnam Chaguturu
Deputy Site Head, Center for Advanced Drug Research
SRI International
VA 22802
USA


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UCSF Small Molecule Discovery Center: Innovation, Collaboration and Chemical Biology in the Bay Area

Author(s): Michelle R. Arkin, Kenny K.H. Ang, Steven Chen, Julia Davies, Connie Merron, Yinyan Tang, Christopher G.M. Wilson and Adam R. Renslo

Affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco; 1700 4th St, Box 2552, San Francisco, CA 94158, USA.

Abstract

The Small Molecule Discovery Center (SMDC) at the University of California, San Francisco, works collaboratively with the scientific community to solve challenging problems in chemical biology and drug discovery. The SMDC includes a high throughput screening facility, medicinal chemistry, and research labs focused on fundamental problems in biochemistry and targeted drug delivery. Here, we outline our HTS program and provide examples of chemical tools developed through SMDC collaborations. We have an active research program in developing quantitative cell-based screens for primary cells and whole organisms; here, we describe whole-organism screens to find drugs against parasites that cause neglected tropical diseases. We are also very interested in target-based approaches for so-called “undruggable”, protein classes and fragment-based lead discovery. This expertise has led to several pharmaceutical collaborations; additionally, the SMDC works with start-up companies to enable their early-stage research. The SMDC, located in the biotech-focused Mission Bay neighborhood in San Francisco, is a hub for innovative small-molecule discovery research at UCSF.

Keywords: Chemical biology, drug discovery, fragment discovery, pharmaceutical industry/academic collaboration, screening, public/private partnership, tropical diseases.

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Article Details

Volume: 17
Issue Number: 4
First Page: 333
Last Page: 342
Page Count: 10
DOI: 10.2174/1386207317666140323133841
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