Label-Free Cell Phenotypic Drug Discovery

ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)


Volume 17, 10 Issues, 2014


Download PDF Flyer




Combinatorial Chemistry & High Throughput Screening

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 23rd of 71 in Chemistry, Applied
  • 47th of 75 in Biochemical Research Methods
  • 152th of 261 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Rathnam Chaguturu
Deputy Site Head, Center for Advanced Drug Research
SRI International
VA 22802
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.0
5 - Year: 1.975

Label-Free Cell Phenotypic Drug Discovery

Author(s): Ye Fang

Affiliation: Biochemical Technologies, Science and Technology Division, Corning Incorporated, Corning, New York 14831, USA.

Abstract

Phenotypic screen holds great potential in the discovery of new small molecule probes and drugs, as it permits interrogating small molecules with native targets and pathways in model organisms and disease relevant cells. In recent years, label-free cell phenotypic profiling has emerged as an alternative for drug discovery. This paper provides the rationale for phenotypic screens, discusses the basics of label-free cell phenotypic profiling technologies, and provides some guidelines as to how to use these techniques to facilitate drug discovery.

Keywords: Label-free cell phenotypic screen, phenotypic screen, polypharmacology, target-directed drug discovery.

Purchase Online Rights and Permissions

Article Details

Volume: 17
Issue Number: 7
First Page: 566
Last Page: 578
Page Count: 13
DOI: 10.2174/1386207317666140211100000
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science