Label-Free Cell Phenotypic Drug Discovery

ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)

Volume 17, 10 Issues, 2014

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Combinatorial Chemistry & High Throughput Screening

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  • 23rd of 71 in Chemistry, Applied
  • 47th of 75 in Biochemical Research Methods
  • 152th of 261 in Pharmacology & Pharmacy

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Rathnam Chaguturu
Deputy Site Head, Center for Advanced Drug Research
SRI International
VA 22802

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Label-Free Cell Phenotypic Drug Discovery

Author(s): Ye Fang

Affiliation: Biochemical Technologies, Science and Technology Division, Corning Incorporated, Corning, New York 14831, USA.


Phenotypic screen holds great potential in the discovery of new small molecule probes and drugs, as it permits interrogating small molecules with native targets and pathways in model organisms and disease relevant cells. In recent years, label-free cell phenotypic profiling has emerged as an alternative for drug discovery. This paper provides the rationale for phenotypic screens, discusses the basics of label-free cell phenotypic profiling technologies, and provides some guidelines as to how to use these techniques to facilitate drug discovery.

Keywords: Label-free cell phenotypic screen, phenotypic screen, polypharmacology, target-directed drug discovery.

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Article Details

Volume: 17
Issue Number: 7
First Page: 566
Last Page: 578
Page Count: 13
DOI: 10.2174/1386207317666140211100000

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