H<sub>3</sub>PW<sub>12</sub>O<sub>40</sub>-Catalyzed Multicomponent Reaction for Efficient Synthesis of Highly Substituted Piperidines

ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)

Volume 18, 10 Issues, 2015

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Combinatorial Chemistry & High Throughput Screening

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H3PW12O40-Catalyzed Multicomponent Reaction for Efficient Synthesis of Highly Substituted Piperidines

Combinatorial Chemistry & High Throughput Screening, 17(6): 503-508.

Author(s): Samad Khaksar, Seyed Meysam Baghbanian and Nastaran Barsan.

Affiliation: Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.


A simple, diastereoselective, inexpensive, and efficient route for the synthesis of highly functionalized piperidines by the condensation of β-keto-esters, aromatic aldehydes and anilines using H3PW12O40 as a catalyst is described. The catalyst could be easily recovered after completion of the reaction and reused without a considerable change in its activity. Furthermore, in most cases the piperidine precipitates out of solution.


Annulation, piperidine, recyclable, tandem, Tungstophosphoric acid.

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Article Details

Volume: 17
Issue Number: 6
First Page: 503
Last Page: 508
Page Count: 6
DOI: 10.2174/1386207316666131229132950

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